Rewinding the Clock: How Yamanaka Factors Are Resetting Aging Cells
Shinya Yamanaka discovered the OSKM factors—Oct4, Sox2, Klf4, and c-Myc—in 2006 to reprogram mature cells into pluripotent stem cells. In 2016, Izpisúa Belmonte and colleagues showed partial in vivo reprogramming in progeria mice by cycling OSKM for 2–4 days with rest, yielding
