Βιολογία

Rewinding the Clock: How Yamanaka Factors Are Resetting Aging Cells
 ·  · 

Γυρίζοντας το Ρολόι Πίσω: Πώς οι Παράγοντες Yamanaka Επαναφέρουν τα Γηρασμένα Κύτταρα

Ο Shinya Yamanaka ανακάλυψε τους παράγοντες OSKM—Oct4, Sox2, Klf4 και c-Myc—το 2006 για να επαναπρογραμματίσει ώριμα κύτταρα σε πολυδύναμα βλαστοκύτταρα. Το 2016, ο Izpisúa Belmonte και οι συνεργάτες του έδειξαν μερικό επαναπρογραμματισμό in vivo σε ποντίκια με προγηρία, κυκλώνοντας τους OSKM για
28 Αυγούστου, 2025

Technology News

  • Thinking Machines Lab loses co-founder to Meta's AI push as Murati-led startup refocuses
    October 14, 2025, 5:21 AM EDT. Thinking Machines Lab, the AI startup cofounded by Mira Murati, confirms that co-founder Andrew Tulloch has left to join Meta's expanding AI division led by Mark Zuckerberg. Tulloch, a former Meta researcher, informed staff on October 10 after 11 years at Meta and a stint at OpenAI. The startup, launched in February 2025, raised about $2 billion and unveiled Tinker, an API for fine-tuning large language models. In a statement, the company said Tulloch's contributions were "foundational" and that it remains focused on finishing what they started together. Meta's push into superintelligence continues through its Superintelligence Labs project, with more than 50 AI experts recruited across OpenAI, Google DeepMind, Anthropic, and Apple. Tulloch's new team at Meta remains undisclosed. Thinking Machines Lab continues under Murati with a team largely from OpenAI, pursuing enterprise AI solutions.
  • TAG Heuer reveals its own OS to boost iPhone compatibility, ditching Wear OS
    October 14, 2025, 5:20 AM EDT. TAG Heuer unveils the Connected Calibre E5 with a proprietary TAG Heuer OS built on Android but not Wear OS, explaining the move as a way to deliver broader iPhone and Android compatibility. After early Wear OS models, the brand now ships a smartwatch that's Made-for-iPhone (MFi) certified and designed to work more seamlessly with iOS. The device features dual-band GPS, health sensors (sleep, heart rate variability, SpO2), a 1.39-inch OLED display with Sapphire Crystal, and a 45mm steel case with a 50m water resistance. Price starts around $1,700 with a Golf Edition at $2,400. The redesign aligns with brands moving away from Wear OS to own software to satisfy iPhone users while keeping Android compatibility.
  • Microsoft Windows 10 End of Life Approaches as Windows 11 Upgrade Tool Faces Bug
    October 14, 2025, 5:19 AM EDT. With Windows 10 reaching End of Life in 24 hours, Microsoft pressures users to upgrade to Windows 11 or enroll in the ESU program for extended security updates. The recent Media Creation Tool update to v26100.6584 reportedly crashes on Windows 10, complicating the upgrade path. Microsoft has published a workaround: use the Windows 11 Installation Assistant to obtain the ISO download and install, though the tool is not supported on Arm64 PCs. The issue underscores a tight deadline for users and businesses alike, as the official date looms and upgrades become more urgent. We'll monitor for further developments and updates on the Windows 10 end-of-life live blog.
  • Thousands of Vodafone customers hit by outage across broadband, 4G and 5G services
    October 14, 2025, 5:18 AM EDT. Thousands of Vodafone customers were affected by an outage spanning broadband, 4G and 5G services. The company said a major issue is impacting its network, with more than 100,000 users reporting problems on DownDetector after around 2pm. Most reports concerned home internet, though a smaller number could not access mobile data. A Vodafone spokeswoman urged patience while engineers work to resolve the fault, which also took offline the company's own website. Vodafone serves more than 18 million customers in the UK, including about 700,000 home broadband customers, and issues were also reported on the Voxi mobile operator.
  • Apple TV+ Rebrands to Apple TV, Dropping the '+' in Streaming Service Name
    October 14, 2025, 5:15 AM EDT. Apple is dropping the '+' from its streaming brand, renaming Apple TV to reflect a new identity. The change coincides with the debut of F1: The Movie and a company-wide push to refresh the service's image. Apple TV has earned 22 Emmys from 27 nominations for The Studio and Severance and remains home to acclaimed series like Ted Lasso, Severance, Shrinking, Slow Horses, The Morning Show, and Pachinko, plus acclaimed films such as CODA and Killers of the Flower Moon. Upcoming originals include Margo's Got Money Troubles, The Savant, Cape Fear, and Lucky, with renewals for The Studio, Murderbot, and Stick. Upcoming titles also include Family Plan 2, Mayday, Matchbox, The Dink, and Outcome.