May 24, 2026, 4:11 AM EDT. Achieving half of Warren Buffett's average 19.9% annual compound growth rate-around 9.95% per year-can realistically grow a Stocks and Shares ISA by approximately 561% over 20 years. Buffett's long-term success at Berkshire Hathaway highlights how smaller investors may have an edge, as investing large sums often makes outsized returns harder. Despite economic uncertainties, opportunities exist in undervalued UK shares, offering potential for growth with a Buffett-inspired strategy focusing on established brands. Fees and commissions also impact ISA performance, so careful selection is essential. This approach favors disciplined, long-term investment and selecting strong, well-managed companies, aligning with Buffett's proven principles.