Rewinding the Clock: How Yamanaka Factors Are Resetting Aging Cells
In 2022, 124-week-old mice treated with inducible OSK via AAV9 and a 1-day-on/6-days-off cycle lived about twice as long in remaining lifespan, with a 9–12% median lifespan extension. Earlier studies showed partial reprogramming with OSKM extended lifespan and improved tissue function in mice. Human cell experiments reset aging markers by about 30 years. Safety concerns, including cancer risk, remain unresolved.